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Results for "

ROS formation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ROS Kinase (1) Akt (1) Aldehyde Dehydrogenase (ALDH) (1) Amyloid-β (1) Angiotensin Receptor (2) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (13) Autophagy (2) Bacterial (1) Calcium Channel (1) Carbonic Anhydrase (1) Cuproptosis (1) Dihydroorotate Dehydrogenase (1) Endogenous Metabolite (2) ERK (1) Ferroptosis (2) Fungal (1) Hexokinase (1) Interleukin Related (2) MDM-2/p53 (1) NADPH Oxidase (1) PI3K (1) Pyroptosis (1) Reactive Oxygen Species (11) Survivin (1) TrxR (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (4) Endocrinology (1) Infection (3) Inflammation/Immunology (2) Metabolic Disease (4) Neurological Disease (2)

By Targets:

ROS Kinase (1)

Akt (1)

Aldehyde Dehydrogenase (ALDH) (1)

Amyloid-β (1)

Angiotensin Receptor (2)

Angiotensin-converting Enzyme (ACE) (1)

Apoptosis (13)

Autophagy (2)

Bacterial (1)

Calcium Channel (1)

Carbonic Anhydrase (1)

Cuproptosis (1)

Dihydroorotate Dehydrogenase (1)

Endogenous Metabolite (2)

ERK (1)

Ferroptosis (2)

Fungal (1)

Hexokinase (1)

Interleukin Related (2)

MDM-2/p53 (1)

NADPH Oxidase (1)

PI3K (1)

Pyroptosis (1)

Reactive Oxygen Species (11)

Survivin (1)

TrxR (1)

By Research Areas:

Cancer (14)

Cardiovascular Disease (4)

Endocrinology (1)

Infection (3)

Inflammation/Immunology (2)

Metabolic Disease (4)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: ROS Kinase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17587

4-Methylbenzylidene camphor 1 Publications Verification 4-MBC; Enzacamene	Apoptosis PI3K Akt ERK	Metabolic Disease
4-Methylbenzylidene camphor (4-MBC) is an endocrine disrupter that produces estrogen-like effects. 4-Methylbenzylidene camphor decreases the proliferation of human trophoblast cells and induces apoptosis. 4-Methylbenzylidene camphor activates PI3K/AKT and ERK1/2 signaling pathways and elevates intracellular ROS production. 4-Methylbenzylidene camphor is a ultraviolet (UV) filter and may hamper normal placental formation during early pregnancy .

HY-23119

Sodium thiocyanate, GR, 99% Thiocyanate sodium	Interleukin Related Reactive Oxygen Species	Inflammation/Immunology
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine IL-10 levels. Sodium thiocyanate also significantly reduces of *ROS* formation .

HY-B1106

Tetrahydroxyquinone Tetrahydroxy-1,4-benzoquinone; Tetrahydroxybenzoquinone	Reactive Oxygen Species Apoptosis	Cancer
Tetrahydroxyquinone (Tetrahydroxy-1,4-benzoquinone), a primitive anticataract agent, is a redox active benzoquinone. Tetrahydroxyquinone can take part in a redox cycle with semiquinone radicals, leading to the formation of reactive oxygen species (ROS) .

HY-B1106A

Tetrahydroxyquinone monohydrate Tetrahydroxy-1,4-benzoquinone monohydrate; Tetrahydroxybenzoquinone monohydrate	Reactive Oxygen Species Apoptosis	Cancer
Tetrahydroxyquinone monohydrate (Tetrahydroxy-1,4-benzoquinone monohydrate), a primitive anticataract agent, is a redox active benzoquinone. Tetrahydroxyquinone monohydrate can take part in a redox cycle with semiquinone radicals, leading to the formation of reactive oxygen species (ROS) .

HY-108992

Deoxynyboquinone	Apoptosis Reactive Oxygen Species	Cancer
Deoxynyboquinone, an excellent NQO1 substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation .

HY-158023

DHODH-IN-26	Dihydroorotate Dehydrogenase Reactive Oxygen Species Ferroptosis	Cancer
DHODH-IN-26 (compound B2) is a mitochondria-targeting DHODH inhibitor. DHODH-IN-26 shows anticancer activity, triggers the formation of reactive oxygen species (ROS), promots mitochondrial lipid peroxidation, and induces ferroptosis .

HY-111447

VAS 3947	NADPH Oxidase Apoptosis	Cardiovascular Disease Cancer
VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins .

HY-146067

β-Nor-lapachone	Fungal Reactive Oxygen Species	Infection
β-Nor-lapachone is a *Candida glabrata* antibiofilm agent. β-Nor-lapachone can stimulate *ROS* production, inhibits efflux activity, adhesion, biofilm formation and the metabolism of mature biofilms of Candida glabrata. β-Nor-lapachone has antifungal activity .

HY-162041

AQIM-I	Survivin	Cancer
AQIM-I is an inhibitor of survivin via inhibits survivin expression and colony formation. AQIM-I induces *ROS* production, apoptosis, cell cycle arrest, DNA damage, and autophagy. AQIM-I inhibits nonsmall cell lung cancer cells A549 with an IC₅₀ value of 9 nM .

HY-14914

Azilsartan 4 Publications Verification TAK-536	Angiotensin Receptor Reactive Oxygen Species Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Azilsartan (TAK-536) is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces *ROS* formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research .

HY-19992

3-Bromopyruvic acid 15+ Cited Publications Bromopyruvic acid; Hexokinase II Inhibitor II, 3-BP	Hexokinase Apoptosis Autophagy	Cancer
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities .

HY-135897

Urolithin C 2 Publications Verification	Calcium Channel Reactive Oxygen Species Apoptosis Endogenous Metabolite	Metabolic Disease
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca ²⁺ channel opener and enhances Ca ²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation .

HY-B0655

Zofenopril calcium SQ26991	Angiotensin-converting Enzyme (ACE) Reactive Oxygen Species	Cardiovascular Disease
Zofenopril Calcium (SQ26991) is an orally active angiotensin-converting enzyme (ACE) inhibitor with antioxidant activity and cardioprotective effects. Zofenopril Calcium reduces ROS production and GSH consumption and helps inhibit foam cell formation, thus slowing the progression of atherosclerosis. Zofenopril Calcium prevents cardiac damage caused by chronic Doxorubicin (HY-15142A).

HY-143413

BuChE-IN-2	Amyloid-β	Neurological Disease Inflammation/Immunology
BuChE-IN-2 is an excellent butyrylcholinesterase (BuChE) inhibitor (IC₅₀s of 1.28 μM and 0.67 μM for BuChE and NO). BuChE-IN-2 can inhibit the aggregation of Aβ, ROS formation and chelate Cu ²⁺, exhibiting proper blood-brain barrier (BBB) penetration. BuChE-IN-2 has potential to research Alzheimer’s disease .

HY-14914S1

Azilsartan-d4 TAK-536-d₄	Apoptosis Angiotensin Receptor Reactive Oxygen Species
Azilsartan-d₄ is the deuterium labeled Azilsartan[1]. Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research[2][3][4][5][6].

HY-146254

hCAIX-IN-12	Carbonic Anhydrase Apoptosis Reactive Oxygen Species	Cancer
hCAIX-IN-12 is a potent hCAIX inhibitor with IC₅₀ values of 0.74, 10.78 µM for CAIX and CAII, respectively. hCAIX-IN-12 shows antiproliferative effect and induces apoptosis. hCAIX-IN-12 increases ROS production. hCAIX-IN-12 has the potential for the research of colorectal cancer (CRC) .

HY-162084

BKN-1	Autophagy Apoptosis	Cancer
BKN-1 is a bifunctional ligand that can not only track the formation of mtG4s (G-quadruplexes, four-stranded DNA structures containing Hoogsteen bonds) through far-red emission, but can also induce mitochondrial dysfunction. BKN-1 has anti-tumor activity and may cause mtDNA loss, damage mitochondrial integrity, reduce ATP levels, and trigger ROS imbalance, leading to apoptosis and autophagy .

HY-B0240

Disulfiram Maximum Cited Publications 47 Publications Verification Tetraethylthiuram disulfide; TETD	Aldehyde Dehydrogenase (ALDH) Interleukin Related Pyroptosis Apoptosis Cuproptosis	Metabolic Disease Cancer
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier, with Cu ²⁺ increases intracellular ROS levels and induces cuproptosis .

HY-F0003

NADPH tetrasodium salt 5+ Cited Publications	Ferroptosis Endogenous Metabolite	Cancer
NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. The demand for NADPH tetrasodium salt is particularly high in proliferating cancer cells, where it acts as a cofactor for the synthesis of nucleotides, proteins, and fatty acids. NADPH tetrasodium salt is also essential for the neutralization of the dangerously high levels of reactive oxygen species (ROS) generated by increased metabolic activity. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis .

HY-146307

TrxR-IN-3	TrxR	Cancer
TrxR-IN-3 (Compound 2c) is a potent inhibitor of TrxR. TrxR-IN-3 exhibits potent antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and resulted in marked apoptosis by regulating apoptosis-related proteins expressed in the breast cancer cells. TrxR-IN-3 also triggers the formation of autophagosomes and autolysosomes by promoting the expression of LC3-II and Beclin-1 and diminishing the expression of LC3-I and p62 proteins .

HY-N2037A

Higenamine hydrochloride 1 Publications Verification Norcoclaurine hydrochloride	MDM-2/p53 ROS Kinase Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Higenamine hydrochloride is a selective LSD1 inhibitor (IC₅₀=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases .

HY-P5740

Cacaoidin	Bacterial	Infection
Cacaoidin is a glycosylated lantibiotic isolated from a Streptomyces cacaoi strain. Cacaoidin has potent antibacterial activity against Gram-positive pathogens including Clostridium difficile .

Cacaoidin	Bacterial	Infection
Cacaoidin is a glycosylated lantibiotic isolated from a Streptomyces cacaoi strain. Cacaoidin has potent antibacterial activity against Gram-positive pathogens including Clostridium difficile .

Cat. No.	Product Name	Category	Target	Chemical Structure